3 ms·
> Transgenic mice with increased amyloid-β (Aβ) production Looks to me they increased amyloid-B then removed the increase, which solved symptoms. I don't know
by Krssst 2y ago
> Transgenic mice with increased amyloid-β (Aβ) production
Looks to me they increased amyloid-B then removed the increase, which solved symptoms. I don't know much about this but my understanding was that Alzheimer disease had to have a bit more going on than just amyloid-B accumulation.
- resoluteteeth 2y agoYes that is the major potential problem with this type of mouse model in general. Mice are modified to have a condition that resembles something like alzheimer's disease and then treatments are tested, but there's no guarantee that the underlying disease is actually the same, so if the condition that is induced in the mice is just a symptom rather than the underlying cause of the human disease, or just superficially resembles it, the treatment may not actually be effective in humans.
- rich_sasha 2y agoMy understanding is, it's definitely true that the amyloid protein is toxic to brain tissue. It's just that targeting that tissue has not, to date, lead to a breakthrough. I suppose in principle it could be because we don't ha e good ways to remove them, and this is it.