3 ms·
Obvious caveat: You REALLY want to research this in-depth to see if there's any basis to it, but I recently came across the fact that Hymecromone(4-methylumbell
by Llamamoe 2y ago
Obvious caveat: You REALLY want to research this in-depth to see if there's any basis to it, but I recently came across the fact that Hymecromone(4-methylumbelliferone) is an inhibitor of Hyaluronic Acid synthesis, which is a part of extracellular matrix, and necessary for cell proliferation, that is currently being investigated for a large range of different cancers, with positive effects in most(mostly animal models and in vitro studies).
I first discovered it when searching for bladder cancer therapies[1][2]
A cursory search seems to say that HA does in fact play a role in GBM[3], and that 4MU appears to reduce GBM cell proliferation[4] though it looks at a different mechanism.
In fact, there seems to be a review of its potential for treating brain cancers specifically[5]
As far as I can tell, it's a commonly prescribed drug for bile acid related issues that rarely has any side effects or risks. It appears to be safe, and to improve outcomes across many types of cancers
[1] https://www.auajournals.org/doi/full/10.1016/j.juro.2014.02.842 https://www.auajournals.org/doi/full/10.1016/j.juro.2014.02....
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC11081427/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11081427/
[3] https://link.springer.com/chapter/10.1007/978-94-007-7602-9_26 https://link.springer.com/chapter/10.1007/978-94-007-7602-9_...
[4] https://www.sciencedirect.com/science/article/pii/S2352304221001057 https://www.sciencedirect.com/science/article/pii/S235230422...
[5] https://www.researchgate.net/profile/Yasser-Mustafa-3/publication/354381262_Hymecromone_and_Its_Products_as_Cytotoxic_Candidates_for_Brain_Cancer_A_Brief_Review/links/6135e54838818c2eaf85d993/Hymecromone-and-Its-Products-as-Cytotoxic-Candidates-for-Brain-Cancer-A-Brief-Review.pdf https://www.researchgate.net/profile/Yasser-Mustafa-3/public...