"The intensity comes down to how grapefruit's compounds mainly furanocoumarins inhibit CYP3A4. Normally, this enzyme would help break down psilocybin into psilo

"The intensity comes down to how grapefruit's compounds mainly furanocoumarins inhibit CYP3A4. Normally, this enzyme would help break down psilocybin into psilocin and metabolize it out of your system. When CYP3A4 is inhibited, more psilocybin remains in your bloodstream longer, allowing for a higher concentration of psilocin to flood your brain at once. This rapid spike in active compound could overwhelm your serotonin receptors, particularly the 5-HT2A receptors, which are the primary target of psilocin." - Found that on erowid years ago, always thought it sounded silly (yet I copied it down ha) - maybe worth giving a go.