Here is a great review by Bailey and colleagues who discovered the risks of grapefruit in drug metabolism. It is from 2013. This is a GREAT example if genotype-

Here is a great review by Bailey and colleagues who discovered the risks of grapefruit in drug metabolism. It is from 2013. This is a GREAT example if genotype-by-drug interaction and why knowing your genotype can be extremely useful. https://pmc.ncbi.nlm.nih.gov/articles/PMC3589309/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3589309/ >Our research group discovered the interaction between grapefruit and certain medications more than 20 years ago [1990s].1–3 Currently, more than 85 drugs, most of which are available in Canada, are known or predicted to interact with grapefruit. This interaction enhances systemic drug concentration through impaired drug metabolism. Many of the drugs that interact with grapefruit are highly prescribed and are essential for the treatment of important or common medical conditions. Recently, however, a disturbing trend has been seen. Between 2008 and 2012, the number of medications with the potential to interact with grapefruit and cause serious adverse effects (i.e., torsade de pointes, rhabdomyolysis, myelotoxicity, respiratory depression, gastrointestinal bleeding, nephrotoxicity) has increased from 17 to 43, representing an average rate of increase exceeding 6 drugs per year. This increase is a result of the introduction of new chemical entities and formulations.