The glymphatic system activity is greatest during slow-waves in N3 (deep) sleep. A slow-wave is the synchronous firing of neurons which is seen as the glymphati

The glymphatic system activity is greatest during slow-waves in N3 (deep) sleep. A slow-wave is the synchronous firing of neurons which is seen as the glymphatic system pumps CBF through the brain. For the past 5 years we've been developing phase-targeted auditory stimulation to increase slow-wave activity, which has been shown to have a positive response in amyloid response, as well as memory, and a bunch of other biomarkers. https://pubmed.ncbi.nlm.nih.gov/38163288/ https://pubmed.ncbi.nlm.nih.gov/38163288/ I link to more research on our website for anyone interested in the space - https://affectablesleep.com/research https://affectablesleep.com/research