3 ms·
After repeated blows simulating a concussion activated the dormant HSV-1 within the brain organoid samples, a significant build-up of amyloid plaque and tangles
by this_steve_j 2y ago
After repeated blows simulating a concussion activated the dormant HSV-1 within the brain organoid samples, a significant build-up of amyloid plaque and tangles of tau protein — key markers of Alzheimer’s disease — was detected. The effect was not observed in uninfected samples.
The study was led by Tufts and Oxford researchers and published in Science Signaling:
Dana M. Cairns et al. Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model. Sci. Signal.18, eado 6430 (2025).
https://science.org/doi/10.1126/scisignal.ado6430 https://science.org/doi/10.1126/scisignal.ado6430
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