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Aspartate signalling drives lung metastasis via alternative translation
- Jimmc414 2y agoArticle: https://medicalxpress.com/news/2025-01-reveal-lung-frequent-site-cancer.html https://medicalxpress.com/news/2025-01-reveal-lung-frequent-...
- Terr_ 2y agoTo pre-empt certain conspiracy theories, yes, aspartate is chemically related to aspartame, but only in a boringly-common way that almost certainly has no causal relationship whatsoever.
- Jimmc414 2y agoI hadn't considered any conspiratorial theories related to this when posting this but since you brought it up isn't ingested aspartame broken down into aspartic acid (aspartate), phenylalanine and methanol? Because one of the breakdown products is aspartic acid, it seems that ingesting aspartame could transiently increase aspartate levels in the bloodstream to some degree. Edit: after doing a little research, I learned that there are _many_ dietary sources of aspartate in the average diet. eg. Beans, soybeans, various grains, eggs, milk, cheese, yogurt, beef, pork, chicken, turkey.
- Terr_ 2y agoYeah, amino acids are ubiquitous in most foods, this chart shows the relative proportions [0], where Aspartic Acid falls under the the cyan "Asp/N" segments. Aspartic acid is "non-essential", meaning we don't require it in our diets, since our cells are quite capable of synthesizing the quantities needed by using other building-blocks. So it shouldn't be weird to see it them using it for a variety of purposes. [0] https://www.researchgate.net/figure/Proportions-of-amino-acids-in-selected-foods-across-food-groups-Amino-acids-are-grouped_fig1_331560091 https://www.researchgate.net/figure/Proportions-of-amino-aci...