3 ms·

The main article is paywalled and appears to be a layman's translation. The first reference (visible in the preview) looks like the biologists' version. https:/

by jprete 2y ago

The main article is paywalled and appears to be a layman's translation. The first reference (visible in the preview) looks like the biologists' version. https://www.nature.com/articles/s41586-024-08165-7 https://www.nature.com/articles/s41586-024-08165-7

jprete 2y ago
I think these are the key findings (from the abstract): "...both human and mouse adipose tissues retain cellular transcriptional changes after appreciable weight loss. Furthermore, we find persistent obesity-induced alterations in the epigenome of mouse adipocytes that negatively affect their function and response to metabolic stimuli. Mice carrying this obesogenic memory show accelerated rebound weight gain, and the epigenetic memory can explain future transcriptional deregulation in adipocytes in response to further high-fat diet feeding." I.e. human and mouse fat cells epigenetically change in response to weight gain*, they don't change back in response to weight loss, and in the mouse case they demonstrated that the mice with the changes gained the weight back faster. I would (naively) expect this to also be true in humans, which would explain why rebound weight gain is incredibly common. I personally see this as significant because it's evidence that obese people and formerly obese people are directly going to have more trouble getting thin, at the level of cell biology, than people who were always thin. *The abstract implies this about human cells but doesn't explicitly say so. I presume it's a known fact about human fat cells.
anenefan 2y ago
Yes it's walled but there are a couple of summary articles [1] [2] From what I came to understand fat cells never really die but lie in wait to do their given job. Now they need to find out why in some people as they age, the fat cells around the gut fights harder to keep it. [1] https://www.smithsonianmag.com/smart-news/fat-cells-retain-a-memory-of-obesity-making-it-hard-to-lose-weight-and-keep-it-off-study-suggests-180985501/ https://www.smithsonianmag.com/smart-news/fat-cells-retain-a... [2] https://www.livescience.com/health/fat-cells-have-a-memory-of-obesity-study-finds https://www.livescience.com/health/fat-cells-have-a-memory-o...

by jprete 2y ago

jprete 2y ago

I think these are the key findings (from the abstract): "...both human and mouse adipose tissues retain cellular transcriptional changes after appreciable weight loss. Furthermore, we find persistent obesity-induced alterations in the epigenome of mouse adipocytes that negatively affect their function and response to metabolic stimuli. Mice carrying this obesogenic memory show accelerated rebound weight gain, and the epigenetic memory can explain future transcriptional deregulation in adipocytes in response to further high-fat diet feeding." I.e. human and mouse fat cells epigenetically change in response to weight gain*, they don't change back in response to weight loss, and in the mouse case they demonstrated that the mice with the changes gained the weight back faster. I would (naively) expect this to also be true in humans, which would explain why rebound weight gain is incredibly common. I personally see this as significant because it's evidence that obese people and formerly obese people are directly going to have more trouble getting thin, at the level of cell biology, than people who were always thin. *The abstract implies this about human cells but doesn't explicitly say so. I presume it's a known fact about human fat cells.

anenefan 2y ago

Yes it's walled but there are a couple of summary articles [1] [2] From what I came to understand fat cells never really die but lie in wait to do their given job. Now they need to find out why in some people as they age, the fat cells around the gut fights harder to keep it. [1] https://www.smithsonianmag.com/smart-news/fat-cells-retain-a-memory-of-obesity-making-it-hard-to-lose-weight-and-keep-it-off-study-suggests-180985501/ https://www.smithsonianmag.com/smart-news/fat-cells-retain-a... [2] https://www.livescience.com/health/fat-cells-have-a-memory-of-obesity-study-finds https://www.livescience.com/health/fat-cells-have-a-memory-o...