I think it's important to offset the modafinil effects with something like amitriptyline. Taking only a stimulant will exacerbate dysautonomia and you'll be fig

I think it's important to offset the modafinil effects with something like amitriptyline. Taking only a stimulant will exacerbate dysautonomia and you'll be fighting a losing battle against your bodies corrective mechanisms. Low Dose Naltrexone works differently to Naltrexone in that the temporary block of the opioid receptor causes a paradoxical natural overreaction to the absence. The mechanism of action is very complex but it appears that the inflammation -> neurotransmitter dysfunction (e.g. dopamine dysregulation)-> immune system dysfunction -> inflammation cycle creates a bit of a trap that people can get stuck in. Taking enough of the right meds on this cycle does appear to help people break out of that trap.