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Modafinil 100mg morning and Amitriptyline 75mg at night helps with dysautonomia, though modafinil can exacerbate gut issues. Using weaker ligands helps with wor

Modafinil 100mg morning and Amitriptyline 75mg at night helps with dysautonomia, though modafinil can exacerbate gut issues. Using weaker ligands helps with working with the natural cycles of the body instead of against it. Low Dose Naltrexone. A fairly high dose of TUDCA and DIM. DIM (3,3'-Diindolylmethane) is a relatively non-toxic selective AhR modulator. Ipamorelin + ModGRF. VIP peptide. A fairly low dose Semaglutide of 0.5mg after a year on it where I started at 0.05mg - not sure if the dose has plateaued, we will see. Elimination of sugar from diet. Resistance exercise and no aerobic exercise due to PEM. I have a strong genetic predisposition (hEDS) so I was impacted by Long Covid worse than most.

ba12367fgh 2y ago
Thank you so much. I've been impacted similarly. If I have some luck I will let you know. (I put my email in my bio, I might have some useful stuff too) :)
93po 2y ago
What is the mechanism of Naltrexone in reducing fatigue? It seems like fatigue and sleepiness is a common side effect. I had really high hopes for modafinil in treating my long-life fatigue issues as well as helping with my severe ADHD since I can't tolerate or access traditional stimulant medication for it rignt now. It was amazing for a week or so but quickly stopped having an effect unless I took 400mg a day, and the side effects of that dose were also not tolerable for me.
- cjbgkagh 2y ago
  I think it's important to offset the modafinil effects with something like amitriptyline. Taking only a stimulant will exacerbate dysautonomia and you'll be fighting a losing battle against your bodies corrective mechanisms. Low Dose Naltrexone works differently to Naltrexone in that the temporary block of the opioid receptor causes a paradoxical natural overreaction to the absence. The mechanism of action is very complex but it appears that the inflammation -> neurotransmitter dysfunction (e.g. dopamine dysregulation)-> immune system dysfunction -> inflammation cycle creates a bit of a trap that people can get stuck in. Taking enough of the right meds on this cycle does appear to help people break out of that trap.
- sudosysgen 2y ago
  Naltrexone is a very weird drug, as it's both an agonist and antagonist of it's target receptor (but mostly an antagonist). As a result paradoxical effects are to be expected.

ba12367fgh 2y ago

Thank you so much. I've been impacted similarly. If I have some luck I will let you know. (I put my email in my bio, I might have some useful stuff too) :)

93po 2y ago

What is the mechanism of Naltrexone in reducing fatigue? It seems like fatigue and sleepiness is a common side effect. I had really high hopes for modafinil in treating my long-life fatigue issues as well as helping with my severe ADHD since I can't tolerate or access traditional stimulant medication for it rignt now. It was amazing for a week or so but quickly stopped having an effect unless I took 400mg a day, and the side effects of that dose were also not tolerable for me.

cjbgkagh 2y ago
I think it's important to offset the modafinil effects with something like amitriptyline. Taking only a stimulant will exacerbate dysautonomia and you'll be fighting a losing battle against your bodies corrective mechanisms. Low Dose Naltrexone works differently to Naltrexone in that the temporary block of the opioid receptor causes a paradoxical natural overreaction to the absence. The mechanism of action is very complex but it appears that the inflammation -> neurotransmitter dysfunction (e.g. dopamine dysregulation)-> immune system dysfunction -> inflammation cycle creates a bit of a trap that people can get stuck in. Taking enough of the right meds on this cycle does appear to help people break out of that trap.
sudosysgen 2y ago
Naltrexone is a very weird drug, as it's both an agonist and antagonist of it's target receptor (but mostly an antagonist). As a result paradoxical effects are to be expected.