Depends on the Application. In Bitcoin farming it famously was not an issue at all, manufacturers came up with the weirdest motherboards featuring many x1 pcie

Depends on the Application. In Bitcoin farming it famously was not an issue at all, manufacturers came up with the weirdest motherboards featuring many x1 pcie slots. Look up the Biostar TB360-BTC PRO 2.0 if you want to see a curiosity. In Deep Learning it depends on your sharding strategy.