Now two questions popped in my head: 1 - Some non-statin antichilesterol drugs work by preventing reabsorption of bile acids, causing them to pass through the

Now two questions popped in my head: 1 - Some non-statin antichilesterol drugs work by preventing reabsorption of bile acids, causing them to pass through the bowels. Can this have the positive side-effect of making lithocholic acid precursors more available to the gut flora downstream? See https://en.m.wikipedia.org/wiki/Bile_acid_sequestrant https://en.m.wikipedia.org/wiki/Bile_acid_sequestrant 2 - Does this affect those who underwent surgery to remove the gallbladder? Say, making caloric restriction more or less effective for this population.