The biochemical effects may not be consciously apparent, at least to most people. All I know for sure is that up to, pehaps, 100ya, most people were in contact

The biochemical effects may not be consciously apparent, at least to most people. All I know for sure is that up to, pehaps, 100ya, most people were in contact with the Earth for many or even most hours of their day. 200ya, we were almost all nearly always grounded. That's but a blip in our bodies' developmental history.