Interesting stuff, I studied a disease called Cornelia de Lange syndrome, which is caused by mutations in these “molecular machines”. Basically these machines (

Interesting stuff, I studied a disease called Cornelia de Lange syndrome, which is caused by mutations in these “molecular machines”. Basically these machines (SMC proteins), grab the DNA then pinch two strands together to make a loop. This lets very distant pieces of DNA interact with each other. When this process is broken, thousands of genes are dysregulated and children suffer some devastating and often fatal developmental disorders.