3 ms·
This is a good question and encapsulates the challenges of food and drug regulation. Yes and no. At certain concentrations, many safe compounds become dangerou
by panabee 2y ago
This is a good question and encapsulates the challenges of food and drug regulation.
Yes and no. At certain concentrations, many safe compounds become dangerous in humans.
Even at tiny doses, foods like peanuts may be safe for the vast majority yet lethal for a minority.
Given how devilishly heterogeneous the human race is, the ideal solution provides safety testing at the individual level, not the population level [0]. But this is years away until computational and biological breakthroughs arrive.
[0] Population level is a misnomer. FDA trial sizes below.
Phase 1: 20 to 100 people
Phase 2: up to several hundred people
Phase 3: 300 to 3,000 people
https://www.fda.gov/patients/drug-development-process/step-3-clinical-research https://www.fda.gov/patients/drug-development-process/step-3...
- EA-3167 2y agoKeep in mind that very commonly accepted safe substances such as carrots or water also become lethal at high enough doses, for all humans. It's often stated, and it can be tiring to hear, but the dose really does make the poison.
- pas 2y agoAnd context matters. Folks with this or that kidney problems can die from basically nothing while the median bloke doesn't even notice that their piss is a tad darker.
- EA-3167 2y agoThat's an excellent point, and of course individuals can have pretty stark differences in metabolism, with the alcohol flush reaction being a great and highly visible example.
- stefantalpalaru 2y ago[dead]