Maybe. OTOH there were native, and are still known, but not in wide use, because of inconvenient side effects. Maybe the common knowledge of how to manage these

Maybe. OTOH there were native, and are still known, but not in wide use, because of inconvenient side effects. Maybe the common knowledge of how to manage these got lost because of societal changes (no more druids/shamans), social taboos (witch hunts) because of churches and so on, and lately modern laws? Just a few of them: https://en.wikipedia.org/wiki/Amanita_muscaria https://en.wikipedia.org/wiki/Papaver https://en.wikipedia.org/wiki/Datura https://en.wikipedia.org/wiki/Claviceps_purpurea and probably some forms of https://en.wikipedia.org/wiki/Cannabis