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Mary Lou Jepsen of openwater.cc [2] has managed to image neurons and other large cell structures deep inside living bodies by phase wave interferometry and desc

Mary Lou Jepsen of openwater.cc [2] has managed to image neurons and other large cell structures deep inside living bodies by phase wave interferometry and descattering signals through human tissues, even through skull and bone[1] using CMOS imageing chips, lasers, ultrasonics and holographics. A thousand times cheaper fMRI. She aims to get to realtime million pixels moving picture resolutions of around a micron. Eventually she will be able to read and write neurons or vibrate and someday maybe burn cell tissues to destruction. There are later presentations at the website where the technique is better described and visualized, but [1] is a good quick place to start and judge if you want to study their brainscanner in more depth. There are patents and a few scientific publications [3] that I'm aware of, but mostly many up to date talks with demonstrations by startup founder Mary Lou [4]. And recently she is open sourcing[5] parts of the hardware and software on github [6] so we can start building our own lab setups and improve the imageing software. [1] https://www.youtube.com/watch?v=awADEuv5vWY https://www.youtube.com/watch?v=awADEuv5vWY [2] https://www.openwater.health/ https://www.openwater.health/ [3] https://scholar.google.com/citations?hl=en&user=5Ni7umEAAAAJ&view_op=list_works&sortby=pubdate https://scholar.google.com/citations?hl=en&user=5Ni7umEAAAAJ... [4] https://www.youtube.com/watch?v=U_cHAH4T8Co https://www.youtube.com/watch?v=U_cHAH4T8Co [5] https://www.youtube.com/watch?v=hNFQtpNHufk https://www.youtube.com/watch?v=hNFQtpNHufk [6] https://github.com/OpenwaterHealth https://github.com/OpenwaterHealth

germinalphrase 2y ago
I remember she did a talk at the Long Now Foundation a while back. My take away - which could be completely wrong - was that they saw the potential to read and write memories.
- KennyBlanken 2y ago
  She can't even answer the FDA on "explain how this will actually treat anything" https://github.com/OpenwaterHealth/opw_regulatory/blob/9e151dde43bbd40daee82584ea5b3a016b6c7f37/Ultrasound/FDA%20Written%20Feedback%20on%20Openwater%20LOFU%20Therapy%20System%20(Q220469).pdf https://github.com/OpenwaterHealth/opw_regulatory/blob/9e151...
westurner 2y ago
From the OpenwaterHealth/opw_neuromod_sw README: https://github.com/OpenwaterHealth/opw_neuromod_sw https://github.com/OpenwaterHealth/opw_neuromod_sw : > open-LIFU uses an array to precisely steer the ultrasound focus to the target location, while its wearable small size allows transmission through the forehead into a precise spot location in the brain even while the patient is moving. Does it use one beam of the array to waveguide another beam? For imaging or for treatment? From "A simple technique to overcome self-focusing, filamentation, supercontinuum generation, aberrations, depth dependence and waveguide interface roughness using fs laser processing" (2017) https://www.nature.com/articles/s41598-017-00589-8 https://www.nature.com/articles/s41598-017-00589-8 https://scholar.google.com/scholar?start=10&hl=en&as_sdt=5,47&sciodt=0,47&cites=11686473802297914479&scipsc= https://scholar.google.com/scholar?start=10&hl=en&as_sdt=5,4... : > We show that all these effects can be significantly reduced if not eliminated using two coherent, ultrafast laser-beams through a single lens - which we call the Dual-Beam technique. Simulations and experimental measurements at the focus are used to understand how the Dual-Beam technique can mitigate these problems. The high peak laser intensity is only formed at the aberration-free tightly localised focal spot, simultaneously, suppressing unwanted nonlinear side effects for any intensity or processing depth. Therefore, we believe this simple and innovative technique makes the fs laser capable of much more at even higher intensities than previously possible, allowing applications in multi-photon processing, bio-medical imaging, laser surgery of cells, tissue and in ophthalmology, along with laser writing of waveguides.
KennyBlanken 2y ago
When the best you can come up with are TED talks and videos on a cryptocurrency youtube channel - and the only claim to fame she has is that she co-founded a miserable failure of a project (One Laptop Per Child) there are serious credibility issues. Is there any peer reviewed research? Is the collaborating with any established, published, respected-in-their-field researchers? After a decade of research, have they shown any actual pathway or mechanism of treatment? They're not helped by the FDA politely saying "you haven't actually said how you intend for this thing to be used" and "your protocols don't actually specify why they are safe" and "no, we're not going to give you shit, because you haven't even done animal studies or clinial studies" and "no, you can't just say that your device has no risk of injury or death": https://github.com/OpenwaterHealth/opw_regulatory/blob/9e151dde43bbd40daee82584ea5b3a016b6c7f37/Ultrasound/FDA%20Written%20Feedback%20on%20Openwater%20LOFU%20Therapy%20System%20(Q220469).pdf https://github.com/OpenwaterHealth/opw_regulatory/blob/9e151... She hasn't even done any animal studies, and went to the FDA seeking approval for a device... These people are a bunch of clowns. The FDA has to explain to them that they could do thermal testing by inserting a themocouple between the device and fake skin on a testing device.

germinalphrase 2y ago

I remember she did a talk at the Long Now Foundation a while back. My take away - which could be completely wrong - was that they saw the potential to read and write memories.

KennyBlanken 2y ago
She can't even answer the FDA on "explain how this will actually treat anything" https://github.com/OpenwaterHealth/opw_regulatory/blob/9e151dde43bbd40daee82584ea5b3a016b6c7f37/Ultrasound/FDA%20Written%20Feedback%20on%20Openwater%20LOFU%20Therapy%20System%20(Q220469).pdf https://github.com/OpenwaterHealth/opw_regulatory/blob/9e151...

westurner 2y ago

From the OpenwaterHealth/opw_neuromod_sw README: https://github.com/OpenwaterHealth/opw_neuromod_sw https://github.com/OpenwaterHealth/opw_neuromod_sw : > open-LIFU uses an array to precisely steer the ultrasound focus to the target location, while its wearable small size allows transmission through the forehead into a precise spot location in the brain even while the patient is moving. Does it use one beam of the array to waveguide another beam? For imaging or for treatment? From "A simple technique to overcome self-focusing, filamentation, supercontinuum generation, aberrations, depth dependence and waveguide interface roughness using fs laser processing" (2017) https://www.nature.com/articles/s41598-017-00589-8 https://www.nature.com/articles/s41598-017-00589-8 https://scholar.google.com/scholar?start=10&hl=en&as_sdt=5,47&sciodt=0,47&cites=11686473802297914479&scipsc= https://scholar.google.com/scholar?start=10&hl=en&as_sdt=5,4... : > We show that all these effects can be significantly reduced if not eliminated using two coherent, ultrafast laser-beams through a single lens - which we call the Dual-Beam technique. Simulations and experimental measurements at the focus are used to understand how the Dual-Beam technique can mitigate these problems. The high peak laser intensity is only formed at the aberration-free tightly localised focal spot, simultaneously, suppressing unwanted nonlinear side effects for any intensity or processing depth. Therefore, we believe this simple and innovative technique makes the fs laser capable of much more at even higher intensities than previously possible, allowing applications in multi-photon processing, bio-medical imaging, laser surgery of cells, tissue and in ophthalmology, along with laser writing of waveguides.

KennyBlanken 2y ago

When the best you can come up with are TED talks and videos on a cryptocurrency youtube channel - and the only claim to fame she has is that she co-founded a miserable failure of a project (One Laptop Per Child) there are serious credibility issues. Is there any peer reviewed research? Is the collaborating with any established, published, respected-in-their-field researchers? After a decade of research, have they shown any actual pathway or mechanism of treatment? They're not helped by the FDA politely saying "you haven't actually said how you intend for this thing to be used" and "your protocols don't actually specify why they are safe" and "no, we're not going to give you shit, because you haven't even done animal studies or clinial studies" and "no, you can't just say that your device has no risk of injury or death": https://github.com/OpenwaterHealth/opw_regulatory/blob/9e151dde43bbd40daee82584ea5b3a016b6c7f37/Ultrasound/FDA%20Written%20Feedback%20on%20Openwater%20LOFU%20Therapy%20System%20(Q220469).pdf https://github.com/OpenwaterHealth/opw_regulatory/blob/9e151... She hasn't even done any animal studies, and went to the FDA seeking approval for a device... These people are a bunch of clowns. The FDA has to explain to them that they could do thermal testing by inserting a themocouple between the device and fake skin on a testing device.