3 ms·

I wonder how many HNers accept this evidence but reject the converging lines of evidence across very different study designs (mendelian randomization, prospecti

I wonder how many HNers accept this evidence but reject the converging lines of evidence across very different study designs (mendelian randomization, prospective cohort, RCTs) that cholesterol (more specifically, apoB) causes heart disease: https://pmc.ncbi.nlm.nih.gov/articles/PMC5837225/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5837225/

shlant 2y ago
also pay attention to how most of the big names who discount the causality of LDL regularly criticize questionnaire-based studies (or Nutritional Epidemiology as a whole), but only when it goes against their personal beliefs.
- hombre_fatal 2y ago
  True, it's a common theme. But even someone who dies on the hill of FFQs has to contend with mendelian randomization and controlled trials.
AnthonBerg 2y ago
Thanks for the paper! For other readers: To expand on this, the paper in the parent comment is “Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel” (2017) – https://pmc.ncbi.nlm.nih.gov/articles/PMC5837225/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5837225/ It refers to a second then-upcoming publication, which I believe is this one: ”Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel” (2020) – https://academic.oup.com/eurheartj/article/41/24/2313/5735221 https://academic.oup.com/eurheartj/article/41/24/2313/573522... The difference between the titles: The 2017 paper discusses genetic, epidemiologic, and clinical studies and the 2020 one looks at pathophysiological, genetic, and therapeutic insights. (Personally, I’m in the pathophysiology-and-molecular-biology-or-GTFO camp. And these papers are good to have.) Thanks again! Just thought I’d share this second paper as I’d gone to look for it anyway.

shlant 2y ago

also pay attention to how most of the big names who discount the causality of LDL regularly criticize questionnaire-based studies (or Nutritional Epidemiology as a whole), but only when it goes against their personal beliefs.

hombre_fatal 2y ago
True, it's a common theme. But even someone who dies on the hill of FFQs has to contend with mendelian randomization and controlled trials.

AnthonBerg 2y ago

Thanks for the paper! For other readers: To expand on this, the paper in the parent comment is “Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel” (2017) – https://pmc.ncbi.nlm.nih.gov/articles/PMC5837225/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5837225/ It refers to a second then-upcoming publication, which I believe is this one: ”Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel” (2020) – https://academic.oup.com/eurheartj/article/41/24/2313/5735221 https://academic.oup.com/eurheartj/article/41/24/2313/573522... The difference between the titles: The 2017 paper discusses genetic, epidemiologic, and clinical studies and the 2020 one looks at pathophysiological, genetic, and therapeutic insights. (Personally, I’m in the pathophysiology-and-molecular-biology-or-GTFO camp. And these papers are good to have.) Thanks again! Just thought I’d share this second paper as I’d gone to look for it anyway.