You can get NAFLD from fructose yes, but it's not the same as alcohol. Alcohol is metabolized in the liver but the pathway is very different. Alcohol dehydroge

You can get NAFLD from fructose yes, but it's not the same as alcohol. Alcohol is metabolized in the liver but the pathway is very different. Alcohol dehydrogenase (and in alcoholics CYP2E1) breaks it down into acetaldehyde. Aldehyde dehydrogenase breaks it down into acetone. Acetone is one of the ketone bodies that's then utilized as a fuel directly. Acetone is a natural ketone, but it's also toxic at high levels. Fructose undergoes fructolysis. Fructose is phosphorylated to fructose-1-phosphate by frucotkinase. It's then broken down by aldolase B into glyceraldehyde and dihydroxyacetone phosphate (DHAP). Glyceraldehyde is converted to glyceraldehyde-3-phosphate and enters mid-way through the glucose metabolism pathway. DHAP is used to synthesize fat. Since it happens in the liver, you can get fat build-up in the liver, and NAFLD.