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Thing I read that's a bit fascinating and possibly important is your digestive system has taste buds and it's own nervous system. I wouldn't be gobsmacked if it

Thing I read that's a bit fascinating and possibly important is your digestive system has taste buds and it's own nervous system. I wouldn't be gobsmacked if it responded to artificial sweeteners. And that causes issues. Other thing I read is fructose is processed by the liver via some of the same paths that alcohol does. Would surprising if they didn't share some of the same negative health outcomes.

arcticbull 2y ago
You can get NAFLD from fructose yes, but it's not the same as alcohol. Alcohol is metabolized in the liver but the pathway is very different. Alcohol dehydrogenase (and in alcoholics CYP2E1) breaks it down into acetaldehyde. Aldehyde dehydrogenase breaks it down into acetone. Acetone is one of the ketone bodies that's then utilized as a fuel directly. Acetone is a natural ketone, but it's also toxic at high levels. Fructose undergoes fructolysis. Fructose is phosphorylated to fructose-1-phosphate by frucotkinase. It's then broken down by aldolase B into glyceraldehyde and dihydroxyacetone phosphate (DHAP). Glyceraldehyde is converted to glyceraldehyde-3-phosphate and enters mid-way through the glucose metabolism pathway. DHAP is used to synthesize fat. Since it happens in the liver, you can get fat build-up in the liver, and NAFLD.