Generally I'm in agreement, but the one place that starts to fall apart is with bindings— if there's a native code library, then I really would prefer that libr

Generally I'm in agreement, but the one place that starts to fall apart is with bindings— if there's a native code library, then I really would prefer that library come in from the native package manager rather than be smuggled in by pip... but that's not generally how it works these days, and outside of Nix there isn't a great way to resolve this case.