3 ms·

I'm not promoting the consumption of ivermectin without a good reason. I've never had it myself, nor have I encouraged anyone else to take it for "funsies". Ty

I'm not promoting the consumption of ivermectin without a good reason. I've never had it myself, nor have I encouraged anyone else to take it for "funsies". Tylenol overdoses are relatively common and can even be deadly, but it would be a gross over-generalization to classify Tylenol as a "risky" drug. If you want people to take a drug in a proper setting, in proper amounts, to treat the relevant disease you should /just say that/ instead of trying to get people to think a generally safe drug isn't generally safe. If someone has a serious bacterial infection and thinks they just need Tylenol, I wouldn't tell them that "You shouldn't take Tylenol! It's risky!" instead I'd tell them that Tylenol won't help treat their disease.

ceejayoz 2y ago
Tylenol is absolutely a risky drug. https://www.propublica.org/article/tylenol-mcneil-fda-use-only-as-directed https://www.propublica.org/article/tylenol-mcneil-fda-use-on... > But the FDA says acetaminophen carries a special risk. About a quarter of Americans routinely take more over-the-counter pain relief pills of all kinds than they are supposed to, surveys show. That behavior is "particularly troublesome" for acetaminophen, an FDA report said, because the drug's narrow safety margin places "a large fraction of users close to a toxic dose in the ordinary course of use.” > Taken over several days, as little as 25 percent above the maximum daily dose – or just two additional extra strength pills a day – has been reported to cause liver damage, according to the agency. Taken all at once, a little less than four times the maximum daily dose can cause death. A comparable figure doesn't exist for ibuprofen, because so few people have died from overdosing on that drug. > From 2001 to 2010, annual acetaminophen-related deaths amounted to about twice the number attributed to all other over-the-counter pain relievers combined, according to the poison control data. > Acetaminophen overdose sends as many as 78,000 Americans to the emergency room annually and results in 33,000 hospitalizations a year, federal data shows. Acetaminophen is also the nation’s leading cause of acute liver failure, according to data from an ongoing study funded by the National Institutes for Health. > In fact, the FDA has still not completed the review of the drug that began back in the 1970s, as part of the agency’s larger mandate to assess the safety and efficacy of older medicines. > As the panel’s work was going on, one of the world’s most prestigious medical journals weighed in on acetaminophen. The London-based Lancet declared in a 1975 editorial that if the drug “were discovered today it would not be approved” by British regulators. “It would certainly never be freely available without prescription.”

ceejayoz 2y ago

Tylenol is absolutely a risky drug. https://www.propublica.org/article/tylenol-mcneil-fda-use-only-as-directed https://www.propublica.org/article/tylenol-mcneil-fda-use-on... > But the FDA says acetaminophen carries a special risk. About a quarter of Americans routinely take more over-the-counter pain relief pills of all kinds than they are supposed to, surveys show. That behavior is "particularly troublesome" for acetaminophen, an FDA report said, because the drug's narrow safety margin places "a large fraction of users close to a toxic dose in the ordinary course of use.” > Taken over several days, as little as 25 percent above the maximum daily dose – or just two additional extra strength pills a day – has been reported to cause liver damage, according to the agency. Taken all at once, a little less than four times the maximum daily dose can cause death. A comparable figure doesn't exist for ibuprofen, because so few people have died from overdosing on that drug. > From 2001 to 2010, annual acetaminophen-related deaths amounted to about twice the number attributed to all other over-the-counter pain relievers combined, according to the poison control data. > Acetaminophen overdose sends as many as 78,000 Americans to the emergency room annually and results in 33,000 hospitalizations a year, federal data shows. Acetaminophen is also the nation’s leading cause of acute liver failure, according to data from an ongoing study funded by the National Institutes for Health. > In fact, the FDA has still not completed the review of the drug that began back in the 1970s, as part of the agency’s larger mandate to assess the safety and efficacy of older medicines. > As the panel’s work was going on, one of the world’s most prestigious medical journals weighed in on acetaminophen. The London-based Lancet declared in a 1975 editorial that if the drug “were discovered today it would not be approved” by British regulators. “It would certainly never be freely available without prescription.”