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No. ARHGAP36[1] stimulates GTP catabolism. And since MC1R is a g protein coupled receptor and uses GTP as an energy source, changes in the levels GTP will chan
by FollowingTheDao 2y ago
No.
ARHGAP36[1] stimulates GTP catabolism. And since MC1R is a g protein coupled receptor and uses GTP as an energy source, changes in the levels GTP will change the response of MC1R[2] to MSH and ACTH. It will react less strongly when there is lower GTP, and more strongly when there is higher GTP[3].
[1]https://www.uniprot.org/uniprotkb/Q6ZRI8/entry https://www.uniprot.org/uniprotkb/Q6ZRI8/entry
[2] https://www.uniprot.org/uniprotkb/Q865E5/entry https://www.uniprot.org/uniprotkb/Q865E5/entry
[3]https://www.nature.com/scitable/content/ne0000/ne0000/ne0000/ne0000/14673543/U4.cp2.1_nature01307-f1.2.jpg https://www.nature.com/scitable/content/ne0000/ne0000/ne0000...