Another fun fact: that these chemicals, fur[an]ocoumarins, are also potent CYP3A4 inhibitors. As such they interact with about ~50% of medications. The most com

Another fun fact: that these chemicals, fur[an]ocoumarins, are also potent CYP3A4 inhibitors. As such they interact with about ~50% of medications. The most common ones are bergamottin and 6',7'-dihydroxybergamottin [1, 2] found in grapefruit juice and in the peels of various citrus fruits like limes. This is why grapefruit juice among other things may cause increased side effects associated with birth control pills. [1] https://en.wikipedia.org/wiki/Bergamottin https://en.wikipedia.org/wiki/Bergamottin [2] https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_intera...