4 ms·

Life-changing cream to treat skin cancer moves closer to reality

• pulvinar 2y ago
  >in organ transplant patients It doesn't say if this has any effect for non-immunosuppresive-related skin cancer.
  • DidYaWipe 2y ago
    Which is the first question you'd ask. Standard journalistic failure.
• gus_massa 2y ago
  It has too few details. It looks like very preliminate research. Clicking here and there, I got this patent https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2021248189 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO20... that appears to be a molecule that disrput https://en.wikipedia.org/wiki/Proline#Cis%E2%80%93trans_isomerization https://en.wikipedia.org/wiki/Proline#Cis%E2%80%93trans_isom...
  • deleted 2y ago
    [deleted]
• uj8efdjkfdshf 2y ago
  Having had a look at it, it seems like this involves a molecule (Q2361) closely related to tacrolimus that is capable of binding to FKBP12 where tacrolimus would normally bind but without affecting the function of FKBP12.[1] This seems to be useful in the specific case of people on long term tacrolimus as it locally antagonises tacrolimus activity in the skin to reduce cancer risk. [1] https://jitc.bmj.com/content/jitc/11/9/e006783.full.pdf https://jitc.bmj.com/content/jitc/11/9/e006783.full.pdf