3 ms·
The bigger problem with brain cancer is crossing the blood-brain barrier, no? I don't think this molecule can do that.
by warfangle 14y ago
The bigger problem with brain cancer is crossing the blood-brain barrier, no?
I don't think this molecule can do that.
- robbiep 14y agoBrain cancers mostly disrupt the blood brain barrier, Which is an organised tissue structure that exists to preserve the microenvironment of the brain against normal fluctuations and insults. Cancer is disorganised tissue that doesn't know how to produce nice neat blood brain barrier tissue organisation
- bedris 14y agoCorrect. This tumor-mediated disorganization of the blood-brain barrier (BBB) is what enables cytotoxic drugs to reach larger cancerous brain lesions, which explains why these growths often show a clinical response. Under normal circumstances, many cytotoxic drugs cannot cross the BBB.