4 ms·

ClinicalTrials.gov link [1] Johns Hopkins link [2] [1] http://clinicaltrials.gov/ct2/show/NCT01056029 http://clinicaltrials.gov/ct2/show/NCT01056029 [2] http

by wkdown 14y ago

ClinicalTrials.gov link [1] Johns Hopkins link [2] [1] http://clinicaltrials.gov/ct2/show/NCT01056029 http://clinicaltrials.gov/ct2/show/NCT01056029 [2] http://www.hopkinsmedicine.org/kimmel_cancer_center/research_clinical_trials/clinical_trials/search_results/J09113 http://www.hopkinsmedicine.org/kimmel_cancer_center/research...

rorrr 14y ago
"This study is currently recruiting participants." Well, get back to us when they find out all the side effects.
- jmj42 14y ago
  Miserable, but not dead? I'll take it.
  - abduhl 14y ago
    You would be surprised how much you might come to regret that choice. Especially when you realize you've only slowed the cancer's growth rate and allowed it to metastasize throughout your body. If you are lucky you will die before you lose major cognitive functions. If you aren't you will slowly lose a grip on everything as you become dependant on others just to survive. There are things much worse than death, especially for the ones you leave behind.
- carbocation 14y ago
  That's like reading the announcement of new software and saying, get back to us when they discover all the bugs. Naturally, there will be adverse events due to toxicity. But unless you have some particular insight into why this should be much worse in this case than for other drugs, merely mentioning that there will be toxicities doesn't really advance the discussion. At least, not as written.
  - rorrr 14y ago
    Do you realize that only 9% of drugs pass from Phase I of clinical trials to the FDA approval? Do you know why? Because the "cure" is worse than what they are supposed to treat.
    - carbocation 14y ago
      Likewise, a small fraction of startups become successful. Also, your allegation is wrong. Generally the reason for failure is not adverse events, but lack of efficacy/effectiveness. Will this likely fail? Yes. Will it likely fail due to adverse events? No. Will it likely fail due to inefficacy/ineffectiveness? Yes.

by wkdown 14y ago

rorrr 14y ago

"This study is currently recruiting participants." Well, get back to us when they find out all the side effects.

jmj42 14y ago
Miserable, but not dead? I'll take it.
- abduhl 14y ago
  You would be surprised how much you might come to regret that choice. Especially when you realize you've only slowed the cancer's growth rate and allowed it to metastasize throughout your body. If you are lucky you will die before you lose major cognitive functions. If you aren't you will slowly lose a grip on everything as you become dependant on others just to survive. There are things much worse than death, especially for the ones you leave behind.
carbocation 14y ago
That's like reading the announcement of new software and saying, get back to us when they discover all the bugs. Naturally, there will be adverse events due to toxicity. But unless you have some particular insight into why this should be much worse in this case than for other drugs, merely mentioning that there will be toxicities doesn't really advance the discussion. At least, not as written.
- rorrr 14y ago
  Do you realize that only 9% of drugs pass from Phase I of clinical trials to the FDA approval? Do you know why? Because the "cure" is worse than what they are supposed to treat.
  - carbocation 14y ago
    Likewise, a small fraction of startups become successful. Also, your allegation is wrong. Generally the reason for failure is not adverse events, but lack of efficacy/effectiveness. Will this likely fail? Yes. Will it likely fail due to adverse events? No. Will it likely fail due to inefficacy/ineffectiveness? Yes.