Not a comparison, but a fairly comprehensive list that I maintain, with github stars as a proxy for popularity: https://github.com/sfermigier/awesome-python-we

Not a comparison, but a fairly comprehensive list that I maintain, with github stars as a proxy for popularity: https://github.com/sfermigier/awesome-python-web-frameworks https://github.com/sfermigier/awesome-python-web-frameworks Note: as you probably know, popularity is not necessarily correlated with "actively maintained". For instance, Hug and Sanic are quite popular, but haven't seen a commit for quite a long time.