Yes via the "--system" option of the different commands. Or via the global "python-preference" option set to "only-system". Cf https://docs.astral.sh/uv/conce

Yes via the "--system" option of the different commands. Or via the global "python-preference" option set to "only-system". Cf https://docs.astral.sh/uv/concepts/python-versions/#adjusting-python-version-preferences https://docs.astral.sh/uv/concepts/python-versions/#adjustin... and https://docs.astral.sh/uv/reference/settings/#python-preference https://docs.astral.sh/uv/reference/settings/#python-prefere...