Having used many *roff variants (e.g., troff, nroff, ditroff, groff) over decades and also having rather extensive experience with LaTeX, I'd now definitely cho

Having used many *roff variants (e.g., troff, nroff, ditroff, groff) over decades and also having rather extensive experience with LaTeX, I'd now definitely choose the latter for any serious typesetting task. Pain points include many customization points: re-creating exact document specifications provided externally, using specific typefaces, creating your own macros... Oh, and leaving ASCII (or ISO-8859-1) for multi-script characters. These are not blocking points (there are ways to overcome them, if you find the solutions), but are still major pains. Today's groff is a very fine software, if you are satisfied with its default settings and your task is in the domain it handles.