Any large city, there are (large) areas I feel pretty comfortable in, especially not in the middle of the night. And there are areas I generally avoid including

Any large city, there are (large) areas I feel pretty comfortable in, especially not in the middle of the night. And there are areas I generally avoid including in cities that I otherwise consider "safe." I do think you need to be aware of the environment generally and, while there is always some risk (anywhere), you can alleviate a lot of it. I'm very familiar with a large northeast metropolitan complex and there are places/times I wouldn't go but lots of places/times I would.