3 ms·
I almost lost a former partner to this disease. Totally changed my life. One of my first projects at my development consulting job was a site build for an org
by kylehotchkiss 2y ago
I almost lost a former partner to this disease. Totally changed my life.
One of my first projects at my development consulting job was a site build for an org working on vaccine candidates, which a decade later, unfortunately haven't crossed the finish line.
So with a fairly personal connection with the disease, and the nonzero chance I could one day develop it myself, I have a personal interest in seeing progress in the space.
I saw an IAVI update the other day stating TB research is currently only funded to the tune of 1 billion a year when they need 6. 10.5 million infections a year reported. Remember the countries where the disease have the biggest impact have limited diagnostic abilities outside of cities and politically, these countries are very quick to pretend the problem is solved when the reality is that TB started speeding up again in the covid days because the care programs for patients then was put on pause.
If you wanna change the world and aren't just out for VC cash, go design a mobile X-Ray unit to take into villages, work on an AI model to diagnose from imagery, and work on figuring out how to speed up the testing because a MGIT machine needing power 24/7 is not the type of equipment you can always get in the places the disease impacts.
Figure out how to get those little mycobacteria suckers to divide quicker in agar (my limited biology education tells me mess up the mycoic acid synthesis without killing it?) and then get people a positive result in 3 days instead of 3 weeks. Remember: the very good blood test (quantiferon gold) is banned in the largest country in the world because it comes back positive for the 1/3 of the population latently infected.
- selimthegrim 2y agoSo this New Yorker article is wrong? https://www.newyorker.com/news/news-desk/how-banning-a-tb-test-will-save-lives-in-india https://www.newyorker.com/news/news-desk/how-banning-a-tb-te...
- kylehotchkiss 2y agoIMO the mistake was using the test in isolation without considering other criteria. Let’s say you have somebody in a village who travels to visit a clinic. Chest xray positive so sputum samples taken. They don’t convert for 3 weeks, but contact is lost with patient. Maybe in this scenario the blood test adds the additional factor needed to start treatment sooner. There’s a lot of other diseases there a blood test can diagnose immediately, and I don’t blame health workers for the confusion, quantiferon is a unique test, but a countrywide education campaign could have worked to keep it as part of the diagnostic tools.
- throwaway4220 2y agoWhy not just teach people to read the x-ray