Honest question, since I know nothing about anti cheat development. Is it really feasible to detect cheats that are not simply "insta lock aim to some player"

Honest question, since I know nothing about anti cheat development. Is it really feasible to detect cheats that are not simply "insta lock aim to some player" on the server side only ? Scripting, or Wallhacks, or cheats like these would be impossible to detect automatically and reliably ? (Without something like CSGO's Overwatch where players rate anonymized replays of potential cheaters)