3 ms·

I got it when I was around 40. Before getting the three doses, I would get 3-4 nasty viral sore throats per year (white blistery lesions, very painful). Now I g

I got it when I was around 40. Before getting the three doses, I would get 3-4 nasty viral sore throats per year (white blistery lesions, very painful). Now I get zero. I was probably on my way to getting throat cancer like Michael Douglas. Hopefully I have avoided or at least forestalled that.

ivewonyoung 2y ago
Thought it doesn't help against the strains that you're already infected with? Hence the min and max ages in the guidance.
- throwitawayfam 2y ago
  There is some evidence that it can help against self inoculation and immune response to an existing infection https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00188/full https://www.frontiersin.org/journals/immunology/articles/10.... https://www.sciencedirect.com/science/article/abs/pii/S0090825818311636 https://www.sciencedirect.com/science/article/abs/pii/S00908...
- abracadaniel 2y ago
  From what I’ve seen, it’s been shown to be effective against existing infections, as well as preventing it from progressing to cancer.
  - Avalaxy 2y ago
    I can't find anything about this, do you have any papers?
    - toomim 2y ago
      I don't think it's been tested in studies, but I can offer that I had hand warts for 7 years until I got the HPV vaccine, and the hand warts suddenly disappeared after dose 2. HPV functions by cloaking itself from your immune system. The reason why treatments like freezing work is not by removing the HPV -- it's by stimulating your immune system to look at the area around the wart. Then your immune system can get past the cloaking, and recognize the HPV, and then it destroys it. So functionally, it makes total sense that the HPV vaccine would clear existing infections, and anecdotally, lots of patients (such as myself) have seen HPV clear after getting the vaccine. It's a shame that our bureaucracy doesn't have the incentives to run the studies to acknowledge it institutionally.
    - wsc981 2y ago
      From my understanding most vaccines have never been compared against placebo trials, but would be happy to be proven wrong, e.g. if you can find a study on HPV vaccine.
      - avidphantasm 2y ago
        First hit on DDG: https://www.nejm.org/doi/full/1 https://www.nejm.org/doi/full/1
        wsc981 2y ago
        Page doesn't seem to work.

ivewonyoung 2y ago

Thought it doesn't help against the strains that you're already infected with? Hence the min and max ages in the guidance.

throwitawayfam 2y ago
There is some evidence that it can help against self inoculation and immune response to an existing infection https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00188/full https://www.frontiersin.org/journals/immunology/articles/10.... https://www.sciencedirect.com/science/article/abs/pii/S0090825818311636 https://www.sciencedirect.com/science/article/abs/pii/S00908...
abracadaniel 2y ago
From what I’ve seen, it’s been shown to be effective against existing infections, as well as preventing it from progressing to cancer.
- Avalaxy 2y ago
  I can't find anything about this, do you have any papers?
  - toomim 2y ago
    I don't think it's been tested in studies, but I can offer that I had hand warts for 7 years until I got the HPV vaccine, and the hand warts suddenly disappeared after dose 2. HPV functions by cloaking itself from your immune system. The reason why treatments like freezing work is not by removing the HPV -- it's by stimulating your immune system to look at the area around the wart. Then your immune system can get past the cloaking, and recognize the HPV, and then it destroys it. So functionally, it makes total sense that the HPV vaccine would clear existing infections, and anecdotally, lots of patients (such as myself) have seen HPV clear after getting the vaccine. It's a shame that our bureaucracy doesn't have the incentives to run the studies to acknowledge it institutionally.
  - wsc981 2y ago
    From my understanding most vaccines have never been compared against placebo trials, but would be happy to be proven wrong, e.g. if you can find a study on HPV vaccine.
    - avidphantasm 2y ago
      First hit on DDG: https://www.nejm.org/doi/full/1 https://www.nejm.org/doi/full/1
      - wsc981 2y ago
        Page doesn't seem to work.