There's a long history of OVT clinical trials, if someone's bored and interested they could try tracking down why they (mostly*) failed. See table 1 for a list

There's a long history of OVT clinical trials, if someone's bored and interested they could try tracking down why they (mostly*) failed. See table 1 for a list (as of 2021, probably incomplete) https://pmc.ncbi.nlm.nih.gov/articles/PMC7913179/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7913179/ * As the article points out, there is one approved OVT therapy.