4 ms·
IMHO: This is the closest thing to a "cure" coming out in the next decade. Like a couple injections a day, wearing a CGM to make sure it is working, no calculat
by grahar64 2y ago
IMHO: This is the closest thing to a "cure" coming out in the next decade. Like a couple injections a day, wearing a CGM to make sure it is working, no calculations, no worry about carb intake.
A lot of the other "cures" involve immunosuppressants which have a ton of bad side effects that can be worse than diabetes.
- cperciva 2y agoA lot of the other "cures" involve immunosuppressants I'm optimistic about the VX-264 approach of islet cell encapsulation. Even if the encapsulation eventually breaks down, using stem cell derived cells (rather than cadaver pancreata) means you could simply replace the implant after a few years.
- deleted 2y ago[deleted]
- dgoldstein0 2y ago"cure" is quite a strong term for something that has to be taken ever day. Even a once a day pill requires a nontrivial patient effort to consistently self administer. Far better than today's manual monitoring of blood sugar to be fair, but we still have to worry about people missing doses and continuing to refill and keep taking such a prescription. Maybe one day it could be made into a infrequent injection? Like if you just had to get a shot from your doctor every few months, perhaps that would be easier patient compliance. There was some new hiv preventative that recently demonstrated something like that, I wonder if the technique could be repurposed or not.
- rincebrain 2y agoI'd be interested to see if you can do something like [1] and then native stem cell derived islets, no isolation required... [1] - https://www.nature.com/articles/s41573-020-00092-2 https://www.nature.com/articles/s41573-020-00092-2