3 ms·
I see a whole bunch of comments here where people have misunderstood the issue. The problem here is not that unanticipated outcomes arose from our intended fix
by Terr_ 2y ago
I see a whole bunch of comments here where people have misunderstood the issue.
The problem here is not that unanticipated outcomes arose from our intended fix.
The problem that the exact edit we planned isn't happening in the first place, because the search-replace tools aren't yet specific and reliable enough.
- function_seven 2y agoThe genetic version of the Clbuttic Mistake? https://thedailywtf.com/articles/The-Clbuttic-Mistake- https://thedailywtf.com/articles/The-Clbuttic-Mistake-
- dmvdoug 2y agoThis is also not quite accurate. The edit is happening, but the problem is the same word appears three times in the same sentence, and the program can’t distinguish them. Specifically, there are three copies of the gene, the active one and two inactive ones. Trying to only edit one, they ended up hitting ay least one of the others as well. That then caused misalignment and other issues for the rest of the neighborhood.
- maxerickson 2y agoIt's both. With 2 or 3 cuts, you have several pieces of DNA that recombine in whatever arrangement. So in addition to the disease not being treated, you have other issues. When the sections are subsequently rejoined, entire gene segments may be misaligned or missing. The medical consequences are unpredictable and, in the worst case, contribute to the development of leukemia.