The place where this really matters is if you're printing the string onto a physical device/surface (eg, the silk screen layer of a PCB) and fine details on som

The place where this really matters is if you're printing the string onto a physical device/surface (eg, the silk screen layer of a PCB) and fine details on some characters like 0/Q can be lost or things warped over time like D/8/B/6/G. Base32 isn't supposed to be human readable and I don't think I've ever seen it printed so I don't think it matters. The point of Base32 is to encode binary in ascii.