4 ms·
Your general skepticism of the impact of diet on autoimmune disease modification is warranted, but only in a very hand-wavy sense. Also… 1. The article does no
by epgui 2y ago
Your general skepticism of the impact of diet on autoimmune disease modification is warranted, but only in a very hand-wavy sense. Also…
1. The article does not claim that diet modification cures autoimmunity
2. Autoimmunity is partly but not wholly genetic, and the genetic component usually can’t be described as “a genetic alteration”— it’s more a collection of a large number of interacting genetic predispositions (and that is usually coupled with various environmental and random factors). Either way, diet and genetics interact in many ways.
3. It is not at all surprising (in general) to find that interventions at the level of lipid metabolism result in measurable changes in disease model biomarkers… Although the specifics are very interesting. This is a great paper.
(biochemist)
- spondylosaurus 2y agoIt does say "protect against," though, which to me raises the question of "protects against to what extent?" Which, related to your point about collections of interacting genes: I ran a Promethease report on my genetic data, and it said I had 15-20 different genes associated with an elevated risk of a particular autoimmune disease that I do, in fact, currently suffer from. So in a case like that, I suspect (but obviously can't say for sure) that protective diets have a much harder battle to fight than for someone who doesn't have all those genes.
- epgui 2y agoThe devil is in the details, but you ask the right questions.