4 ms·
Diet-dependent host metabolite shape gut microbiota to protect from autoimmunity
- alejohausner 2y agoTypo in title: "shape" should be "shapes". Otherwise it's just a string of nouns.
- pazimzadeh 2y agoit says shapes on mine
- sandwichsphinx 2y agoTitle character limit, adding the "s" results in >1 too long
- CBLT 2y agoI find it more readable to have shapes, maybe change microbiota to microbiom to save a character?
- rokob 2y agoIn mice
- epgui 2y agoThis is a very valid comment, for once— especially as we’re talking about a disease model rather than the disease itself. Nonetheless, we gain very important and interesting mechanistic insights from this, which truly helps us better understand human pathobiology. (biochemist)
- adamredwoods 2y agoI've never believed that changing one's diet will cure autoimmune diseases. The autoimmunity is from a genetic alteration. Diet could possibly help dampen effects, but diet is difficult to control, not just "willpower" but environmental exposure, and the metabolic pathways are long and quite diverse from person to person. The bigger question is how do we control the gut microbiota effectively and accurately? ALSO, I must point out: >> Consumption of a high-fat, low-carbohydrate ketogenic diet (KD) improves MS-related symptoms in humans This is a SKEPTICAL claim, as the footnote trial references used do NOT state this.
- lm28469 2y agoMost people have an incredibly shitty diet that can be improved 10x by implementing simple rules. Some people are ignorant, some people are lazy, some people are addicted, some people straight up don't care My dad didn't even know the difference between carbs and sugar, as in if his doctor told him to eat 100gr of carbs per day he wouldn't know what's best between sweet potatoes or pure white sugar. It's almost like not knowing you need o2 to breath or water to survive
- adamredwoods 2y agoOne would hope, and perhaps I'm wrong here, that people with serious autoimmune diseases are past this phase, and have already tried altering their diet to improve their symptoms and extend their lives.
- FrustratedMonky 2y ago"Diet could possibly help dampen effects" If you are on the Standard American Diet, and having autoimmune disorders, then improving any diet can 'dampen', and that might be enough. Don't think anybody thinks diet is a 'cure' of autoimmune disorders, just some improvement.
- theGnuMe 2y agoAll of your statements are inconsistent with what we actually know.
- epgui 2y agoYour general skepticism of the impact of diet on autoimmune disease modification is warranted, but only in a very hand-wavy sense. Also… 1. The article does not claim that diet modification cures autoimmunity 2. Autoimmunity is partly but not wholly genetic, and the genetic component usually can’t be described as “a genetic alteration”— it’s more a collection of a large number of interacting genetic predispositions (and that is usually coupled with various environmental and random factors). Either way, diet and genetics interact in many ways. 3. It is not at all surprising (in general) to find that interventions at the level of lipid metabolism result in measurable changes in disease model biomarkers… Although the specifics are very interesting. This is a great paper. (biochemist)