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> If I was researching in this field surely this is the first thing I’d try? Let me ask a clarifying question: Are you saying that the first thing you would ha

> If I was researching in this field surely this is the first thing I’d try? Let me ask a clarifying question: Are you saying that the first thing you would have tried is to synthesize bivalent molecules that link ligands of the transcription factor B cell lymphoma 6 (BCL6) to inhibitors of cyclin-dependent kinases (CDKs)? Or are you just saying that you would have tried to drive cancer cells to self-destruct (but have no clue how)?

aetherspawn 2y ago
With a little domain knowledge and research you find out pretty quickly that: BCL6 is lymphoma. CDK regulate cell death, amongst other things. So yes, I am saying that it seems very straightforward as an approach to attempt to trigger a CDK cell death when BCL6 is present. It seems hard to believe that it is presented as novel with the amount of funding that has been spent on cancer.
- krisoft 2y ago
  > With a little domain knowledge and research you find out pretty quickly That's cool. Where do you think that domain knowledge comes from? Did we just found it in a fortune cookie? Or does the cancer research conducted has something to do with that we have this knowledge? > BCL6 is lymphoma. That's not correct. BCL6 is a protein, or a gene which codes that protein. Mutations in BCL6 can lead to B cell lymphomas. BCL6 is not lymphoma. > I am saying that it seems very straightforward as an approach to attempt to trigger a CDK cell death when BCL6 is present. Excellent. Sounds like you are an oracle of oncological research roadmap. What should be the next target to develop drugs for?
  - aetherspawn 2y ago
    I am glad that you know these things, but cancer research has still failed society as a whole. 3 of my immediate family have had cancer, 2 took chemo and it ruined their lives (it caused weak bones, their spines to virtually dissolve, which led to surgeries to insert plates and things, which have failed multiple times, it has been a mess). The third was not eligible for chemo because they were too sick and they had an existing case of lupus. So we started trying things -- probably 100 different things at first. What worked for them is taking Sanguinaria canadensis daily orally. It is now 15 years later and they still have cancer but are living a normal and healthy life. You know, despite being the most effective treatment you could possibly hope for in this situation (besides an actual cure), there are only a few papers on Sanguinaria canadensis, and most research discredits it. Other friends of mine have tried chemo and died in a horrible way. Now you understand my criticism of cancer research. For all the money that has been spent, the most viable treatment available through a hospital is still a living nightmare.
    - krisoft 2y ago
      First of all: terribly sorry about your loss. > cancer research has still failed society as a whole. How do you distinguish cancer research failing society vs cancer being a damn hard problem and cancer researchers doing their best they can do?

aetherspawn 2y ago

With a little domain knowledge and research you find out pretty quickly that: BCL6 is lymphoma. CDK regulate cell death, amongst other things. So yes, I am saying that it seems very straightforward as an approach to attempt to trigger a CDK cell death when BCL6 is present. It seems hard to believe that it is presented as novel with the amount of funding that has been spent on cancer.

krisoft 2y ago
> With a little domain knowledge and research you find out pretty quickly That's cool. Where do you think that domain knowledge comes from? Did we just found it in a fortune cookie? Or does the cancer research conducted has something to do with that we have this knowledge? > BCL6 is lymphoma. That's not correct. BCL6 is a protein, or a gene which codes that protein. Mutations in BCL6 can lead to B cell lymphomas. BCL6 is not lymphoma. > I am saying that it seems very straightforward as an approach to attempt to trigger a CDK cell death when BCL6 is present. Excellent. Sounds like you are an oracle of oncological research roadmap. What should be the next target to develop drugs for?
- aetherspawn 2y ago
  I am glad that you know these things, but cancer research has still failed society as a whole. 3 of my immediate family have had cancer, 2 took chemo and it ruined their lives (it caused weak bones, their spines to virtually dissolve, which led to surgeries to insert plates and things, which have failed multiple times, it has been a mess). The third was not eligible for chemo because they were too sick and they had an existing case of lupus. So we started trying things -- probably 100 different things at first. What worked for them is taking Sanguinaria canadensis daily orally. It is now 15 years later and they still have cancer but are living a normal and healthy life. You know, despite being the most effective treatment you could possibly hope for in this situation (besides an actual cure), there are only a few papers on Sanguinaria canadensis, and most research discredits it. Other friends of mine have tried chemo and died in a horrible way. Now you understand my criticism of cancer research. For all the money that has been spent, the most viable treatment available through a hospital is still a living nightmare.
  - krisoft 2y ago
    First of all: terribly sorry about your loss. > cancer research has still failed society as a whole. How do you distinguish cancer research failing society vs cancer being a damn hard problem and cancer researchers doing their best they can do?