> The long-term side effects of GLP-1 drugs are not well-studied GLP-1 is a hormone that is released every time you eat, and the drugs are virtually identical

> The long-term side effects of GLP-1 drugs are not well-studied GLP-1 is a hormone that is released every time you eat, and the drugs are virtually identical hormones at natural levels that take ~100x longer (half life of a couple hours) to be excreted. It's a tiny amount of one more peptide among millions- that part is certainly safe. If there's any issue with the drug it would be from the constant activation of a natural hormone receptor. Like how anabolic steroids can hurt you, and TRT can affect your natural testosterone production. Maybe after 10 years it breaks your natural satiety system and makes you always/never hungry. That kind of thing would probably show up in mouse models. Either way- obesity is the largest cause of lost years in the first world and it isn't close. If you are obese your whole life you die 10-15 years earlier and are sicker. It's not going to kill you as fast as untreated t2 diabetes, but in both cases it would be crazy not to take a drug that can just make those problems just go away.