If they turn the tide on obesity at a population level in the western world, they will be right up there in the top category in how they have changed society at

If they turn the tide on obesity at a population level in the western world, they will be right up there in the top category in how they have changed society at a fundamental level. There is ample evidence this is likely to be the case barring any unforeseen long-term side effects. At an individual level of course the argument gets far more nuanced. Time will tell. Reducing obesity rates from 50%+ to 10% would put it firmly in that category for me and most others. 2 years or so ago I started telling friends that this class of drug will end up being seen as the most important drug development since antibiotics when held against the impact it will have upon western societies. I still stand by that, even ignoring the supposed ancillary benefits aside from simple weight loss. The largest negative anyone can point to at the moment is fear of the unknown and the current cost. The latter will resolve itself rapidly - you can already get a weekly dose sourced for less than a cup of coffee if you are feeling a bit more adventurous than most, which suggests the costs will rapidly crash once competition enters the market en-force. It would be of course far better to change Western diets and lifestyle - but that is basically solving the impossible. This is the next best thing.