3 ms·

What about people who, with their current habits, are on the bottom range of what is considered "normal" weight (in the BMI sense) or already underweight? Woul

• riwsky 2y ago
  They just need to take GLP+1, instead.
  • throwup238 2y ago
    It's the number one recommended supplement by the American Society for Cannibals. The flavor is in the fat!
• kubectl_h 2y ago
  > Wouldn't taking GLP-1 (for potential non-weight-loss benefits) be potentially harmful as it may reduce eating even further and lead to being significantly underweight? Almost certainly at the weight loss dosages people are taking now, but semaglutide (at least) can be tuned up and down for effect. Time will tell what kind of dosage is required for these non-weight-loss benefits. That said, I think it's more important to focus on how this drug works -- it works in the brain and in specific areas of the brain that we now know are important for weight loss/addiction/inflammation(?) (because of these emergent miracle drug effect). It doesn't seem outside the realm of possibility that drug companies will be able to target these systems with more finesse in the future as opposed to superdosing engineered stable GLP-1 molecules that flood the system. It is the future understanding of what this drug does that is the real promise for all people -- we are just in the early stages of understanding what we've found.
• loeg 2y ago
  Sure, it would probably not be helpful to give these people medical anorexia unless there was some huge, huge, more-than-offsetting other benefit. (Less than 2% of the US population is considered underweight by BMI: https://www.kff.org/other/state-indicator/distribution-of-body-mass-index-among-adults/ https://www.kff.org/other/state-indicator/distribution-of-bo... . )
• nonameiguess 2y ago
  If it really is inflammation, exercise targets that just as well, and also acts as a miracle drug that seems to reduce the risk of just about everything, somewhat paradoxically even orthopedic injuries over a long enough timescale (because you stave off age-related muscle and bone mineral loss). But that puts us back in the "telling people to exercise doesn't cause them to actually do it" at the public health level. For you yourself, you can simply live a less risky, healthier life. For all yous, probably we need something like a once-weekly pill or injection that doesn't require drastic habit changes. For all of society on a forever timescale, of course, we can ignore the fact that adults won't change their ways and focus on instilling lifelong athlete habits in kids. Doesn't seem to be the direction we're going in, though.
  • pixl97 2y ago
    Things like GLP-1 can give a near immediate bodily response that can lead to people starting to work out. When you have inflammation issues I can promise the last thing you want to do is put stress on your body from working out. Especially when most people don't know how to do it properly.
• leetnewb 2y ago
  Obviously subject to conversation with their doctor, but my endocrinologist suggested against this class of drugs for blood sugar control.