3 ms·

GLP-1 of course is the GLP-1 agonist created by the body. I don't think that humans eat to obesity by default. People have had adequate food for quite long and

by zosima 2y ago

GLP-1 of course is the GLP-1 agonist created by the body. I don't think that humans eat to obesity by default. People have had adequate food for quite long and not grown fat. Maybe there is something in out environment or our foods that are blocking the GLP-1 receptor? If a modern food company discovered something like that they'd immediately realize that (unintentionally) they sell better, probably without realizing what they had created.

matthewdgreen 2y ago
A good amount of GLP-1 is made in the intestines, and production is heavily affected by interactions between those cells and gut bacteria. So anything that caused dysbiosis of the gut microbiome could potentially be causing problems with natural GLP-1 emissions, e.g., antibiotics in the food supply, emulsifiers, etc.
eropple 2y ago
> People have had adequate food for quite long and not grown fat. That's revisionist, both in terms of "for quite long" (food insecurity was common in America until about World War II, and massive food surplus available at consumer-cheap prices begins a little later; other countries still suffer from food insecurity today) and that people haven't grown fat when able to do so. Being wealthy enough to the point of being able to be fat has been A Thing for a thousand years. We know this because the medieval Catholic Church felt that they had to preach moderation; if they had to preach it, it's because it wasn't happening as a universality.
- smileysteve 2y ago
  Also revisionist is sedentary lifestyle, which still isn't as true in many regions of the world. In the past 50 years, we have the normalization of computers / fax machines, fast food, fast commercial air travel. In the past 75 years, we have the normalization of suburbs, television, and personal automobiles, personal phones.
drowsspa 2y ago
Not really. Being fat was a sign of being rich back then, because only rich people could even have enough surplus calories to get fat.
smileysteve 2y ago
Modern food companies did discover this; through concentrated sugars and reduced fiber, arguably with increased use of oils too. Side effects: - Additional Consumption (sugar, HFSS, caffeine, etc) - Lack of Satiation (less fiber) - Quicker to Grow food (less fiber) - Longer shelf life (less fiber, more oil)

by zosima 2y ago

matthewdgreen 2y ago

A good amount of GLP-1 is made in the intestines, and production is heavily affected by interactions between those cells and gut bacteria. So anything that caused dysbiosis of the gut microbiome could potentially be causing problems with natural GLP-1 emissions, e.g., antibiotics in the food supply, emulsifiers, etc.

eropple 2y ago

> People have had adequate food for quite long and not grown fat. That's revisionist, both in terms of "for quite long" (food insecurity was common in America until about World War II, and massive food surplus available at consumer-cheap prices begins a little later; other countries still suffer from food insecurity today) and that people haven't grown fat when able to do so. Being wealthy enough to the point of being able to be fat has been A Thing for a thousand years. We know this because the medieval Catholic Church felt that they had to preach moderation; if they had to preach it, it's because it wasn't happening as a universality.

smileysteve 2y ago
Also revisionist is sedentary lifestyle, which still isn't as true in many regions of the world. In the past 50 years, we have the normalization of computers / fax machines, fast food, fast commercial air travel. In the past 75 years, we have the normalization of suburbs, television, and personal automobiles, personal phones.

drowsspa 2y ago

Not really. Being fat was a sign of being rich back then, because only rich people could even have enough surplus calories to get fat.

smileysteve 2y ago

Modern food companies did discover this; through concentrated sugars and reduced fiber, arguably with increased use of oils too. Side effects: - Additional Consumption (sugar, HFSS, caffeine, etc) - Lack of Satiation (less fiber) - Quicker to Grow food (less fiber) - Longer shelf life (less fiber, more oil)