>If it was that simple, why didn't the human body just evolve to excrete GLP-1 agonists? Or modify GLP-1 itself? Honestly? I'm not much of a physiologist, but

>If it was that simple, why didn't the human body just evolve to excrete GLP-1 agonists? Or modify GLP-1 itself? Honestly? I'm not much of a physiologist, but based on the effects regarding addictions like tobacco or narcotics that cannot be causally downstream just of diet, I'd wonder if GLP-1 agonists aren't actually impacting stress-interoception systems rather than just hunger and metabolism. Under that hypothesis, the evolutionary reason would be: because we evolved to undergo stress mostly in physically strenuous, energy-burning situations, while high loads of cognitive and emotional stress without physical effort are a novelty to post-industrial lifestyles.