my opinion is that targeting mTOR is fruitless because it's so broad and integral to life that it's like a self-righting ship or trying to sink a life preserver

my opinion is that targeting mTOR is fruitless because it's so broad and integral to life that it's like a self-righting ship or trying to sink a life preserver. as described in the conclusion: "This may be explained by the inability of rapamycin to completely block mTORC1-mediated signaling events, the presence of several feedback loops, and the upregulation of compensatory pathways that promote cell survival and growth." targeting mTOR is like saying "let's write a bug that takes down Linux"... the community isn't going to let that happen