4 ms·
AGEs could also simply be markers of poor lifestyle.
by ta988 2y ago
AGEs could also simply be markers of poor lifestyle.
- tuukkah 2y agoSure, and especially if seared steaks and other high-dAGE foods are considered as a marker of poor lifestyle. But if you are saying it's just correlation you're wrong, because the research has also described the mechanism. Wikipedia has a nice list of the effects: https://en.wikipedia.org/wiki/Advanced_glycation_end-product#Effects https://en.wikipedia.org/wiki/Advanced_glycation_end-product... > "In the context of cardiovascular disease, AGEs can induce crosslinking of collagen, which can cause vascular stiffening and entrapment of low-density lipoprotein particles (LDL) in the artery walls. AGEs can also cause glycation of LDL which can promote its oxidation. Oxidized LDL is one of the major factors in the development of atherosclerosis." > "AGEs have been implicated in Alzheimer's Disease,cardiovascular disease, and stroke. The mechanism by which AGEs induce damage is through a process called cross-linking that causes intracellular damage and apoptosis." (AGE is a bad search term but the term glycotoxin is used as well.)