> Results: >A total of 95 youth were enrolled in the GnRHa cohort. Mean age was 11.22 years (SD=1.46), and the majority were white (52.6%) and designated male a

> Results: >A total of 95 youth were enrolled in the GnRHa cohort. Mean age was 11.22 years (SD=1.46), and the majority were white (52.6%) and designated male at birth (51.6%). Elevated depression symptoms were endorsed by 28.6% of GnRHa cohort youth, and 22.1% endorsed clinically significant anxiety. About a quarter (23.6%) endorsed lifetime suicidal ideation, with 7.9% reporting a past suicide attempt. A total of 316 youth were enrolled in the GAH cohort. Mean age was 16.0 years (SD=1.88), and the majority were white (62%) and designated female at birth (64.9%). Elevated depression symptoms were endorsed by 51.3% of the GAH cohort, and 57.3% endorsed clinically significant anxiety. Two-thirds (66.6%) endorsed lifetime suicidal ideation, with 24.6% reporting a past suicide attempt. Life satisfaction was lower amongst both cohorts compared to population-based norms. https://pmc.ncbi.nlm.nih.gov/articles/PMC7897328/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7897328/ This abstract is linked in the article