Just to give a case in point on detection: if you autopsy men over 80 that die of unrelated causes, 80% have evidence of prostate cancer (see Dr Gleason study).

Just to give a case in point on detection: if you autopsy men over 80 that die of unrelated causes, 80% have evidence of prostate cancer (see Dr Gleason study). You can imagine how sensitive detection/incidence amongst this cohort is to detection bias.